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Hugo Kubinyi Microwaves in Organic and Medicinal Chemistry


The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.

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Hugo Kubinyi Microwaves in Organic and Medicinal Chemistry


Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation and equipment. The main part of the book then goes on to systematically survey the complete range of published microwave-assisted synthesis methods from their beginnings in the 1990s to mid-2011, drawing on data from more than 5,000 reports and publications. Throughout, the focus is on those reactions, reagents and reaction conditions that work, and that are the most relevant for medicinal and natural products chemistry. A much expanded section is devoted to combinatorial, highthroughput and flow chemistry methods.

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Jason Tierney Microwave Assisted Organic Synthesis


The first reports on the application of microwaves in organic synthesis date back to 1986, but it was not until the recent introduction of specifically designed and constructed equipment, which countered the safety and reproducibility concerns, that synthetic application of microwaves has become established as a laboratory technique. Microwave assisted synthesis is now being adopted in many industrial and academic laboratories to take advantage of the novel chemistry that can be carried out using a variety of organic reaction types. This book demonstrates the underlying principles of microwave dielectric heating and, by reference to a range of organic reaction types, it’s effective use in synthetic organic chemistry. To illustrate the impact microwave assisted organic synthesis can have on chemical research, case studies drawn mainly from the pharmaceutical industry are presented.

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Satoshi Horikoshi Microwaves in Catalysis. Methodology and Applications


A comprehensive overview covering the principles and preparation of catalysts, as well as reactor technology and applications in the field of organic synthesis, energy production, and environmental catalysis. Edited and authored by renowned and experienced scientists, this reference focuses on successful reaction procedures for applications in industry. Topics include catalyst preparation, the treatment of waste water and air, biomass and waste valorisation, hydrogen production, oil refining as well as organic synthesis in the presence of heterogeneous and homogeneous catalysts and continuous-flow reactions. With its practical relevance and successful methodologies, this is a valuable guide for chemists at universities working in the field of catalysis, organic synthesis, pharmaceutical or green chemistry, as well as researchers and engineers in the chemical industry.

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John N. Sahalos Tunable Materials with Applications in Antennas and Microwaves

Hugo Kubinyi Nuclear Receptors as Drug Targets


Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

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Hugo Kubinyi Lipophilicity in Drug Action and Toxicology


In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from leading experts. It offers a thorough and highly topical survey of this rapidly developing field of research. Color plates demonstrating structural aspects, a vast number of references, and the straightforward presentation of the material make this volume a invaluable tool for all researchers involved in drug design or in the investigation of drug action.

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Hugo Kubinyi High-Throughput Screening in Drug Discovery


Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

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Hugo Kubinyi Prodrugs and Targeted Delivery. Towards Better ADME Properties


This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

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Manoj Gupta Microwaves and Metals


Using microwaves to treat metal-based materials is rapidly emerging as an energy-efficient tool to interact with metals for a number of processes such as sintering, melting, brazing, carburizing and annealing. Microwaves can sinter a wide variety of metal compacts with comparable or enhanced end properties, while at the same time delivering tremendous energy savings over conventional sintering. Microwave processes are therefore gaining increasing attention and adoption in both academia and industry. Gupta and Wong have written this comprehensive text to introduce readers to the world of microwaves and the interaction of microwaves with metals and metals-based formulations. The authors have combined numerous research results from a wide range of sources alongside their own work in the field. Also included are overviews of microwave heating of other non-metal materials and the equipment used for microwave-assisted metallurgy. With microwave techniques poised for widespread adoption, Microwaves and Metals is an essential text for all metallurgists and materials engineers. Provides a thorough grounding in microwave fundamentals and their application to metals processing Informs readers of the latest developments in the field Presents a convenient single source for all aspects of microwave processing of metals and materials Contains liberal illustration to compare and benchmark research results Introduces all the necessary equipment, preparing readers for real-world practice Microwaves and Metals is ideal for a post-graduate or advanced undergraduate course in materials science or metallurgy. Materials and metallurgical engineers in industry, who are keen on cheaper, faster techniques, will also benefit from this book.

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Microwaves in Organic and Medicinal Chemistry Methods and ...

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Microwaves in Organic and Medicinal Chemistry von: C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Hugo Kubinyi – Wikipedia

Hugo Kubinyi (* 1940 in Wien) ist ein österreichischer Chemiker (Pharmazeutische Chemie, Wirkstoffdesign).. Kubinyi studierte ab 1958 Chemie in Wien und wurde 1965 an der Ludwig-Maximilians-Universität München bei Adolf Butenandt und Erich Hecker promoviert (Isolierung, Struktur und Partialsynthese biologisch aktiver Naturstoffe aus Crotonöl), wobei die Dissertation am Max-Planck-Institut ...

Wiley: Microwaves in Organic and Medicinal Chemistry, 2nd ...

Microwaves in Organic and Medicinal Chemistry, 2nd, Completely Revised and Enlarged Edition. C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) ISBN: 978-3-527-64784-2. E-book. 600 pages. March 2013. US $169.99 Purchase This E-book. This price is valid for United States. Change location to view local ...

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by Friedlieb Pfannkuch (Editor), Laura Suter-Dick (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor) January 2015, Hardcover (E-book also available) US $195.00 Buy. In vivo Models for Drug Discovery, Volume 62. by Jose M Vela (Editor), Rafael Maldonado (Editor), Michel Hamon (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series ...

Microwaves in Organic and Medicinal Chemistry, Second ...

Main Microwaves in Organic and Medicinal Chemistry, Second Edition Microwaves in Organic and Medicinal Chemistry, Second Edition Prof. Dr. C. Oliver Kappe , Dr. Alexander Stadler , Dr. Doris Dallinger(auth.) , Raimund Mannhold , Hugo Kubinyi , Gerd Folkers(eds.)

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Hugo Kubinyi, www.kubinyi.de Kriterien für eine „gute“ Leitstruktur (Schering) Molgewicht 200 bis 500 Log P / Log D -1 bis 5 Donorgruppen 0 bis 5 Akzeptorgruppen < 10 Löslichkeit in Wasser 5 mg L-1 (oder 10 x IC 50) biol. Aktivität 100 nM – 1 mM aktiv in zellulärem Testsystem Selektivität > 10-fach (abhängig von Target) ausreichende Permeabilität in CaCo-Zellen Stabilität in ...

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HUGO KUBINYI PDF - Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication. Skip to content. Menu. Flash News. H2160MW9 MANUAL PDF CATALOGO BUJIAS BERU PDF KULTURSCHOCK VIETNAM PDF DECRETO DEL 5 DE NOVIEMBRE DE 2007 IETU PDF CASTROL SAF-XJ 75W-140 PDF ERITEMA PIGMENTADO FIJO POR MEDICAMENTOS PDF ...

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HUGO KUBINYI PDF - goddess-of-desire.info

Professor Kubinyi is a Professor of Pharmaceutical Chemistry of. Köp böcker av Hugo Kubinyi: Pharmacokinetics and Metabolism in Drug Design; Chemogenomics in Drug Discovery; Chemoinformatics in Drug Discovery . Author: Tusar Dogar: Country: Switzerland: Language: English (Spanish) Genre: History: Published (Last): 12 August 2009: Pages: 453: PDF File Size: 1.45 Mb: ePub File Size: 11.29 Mb ...

Microwaves in Organic and Medicinal Chemistry (Methods and ...

Buy Microwaves in Organic and Medicinal Chemistry (Methods and Principles in Medicinal Chemistry) by Kappe, C. Oliver, Stadler, Alexander, Mannhold, Raimund, Kubinyi, Hugo, Folkers, Gerd (ISBN: 9783527312108) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders.

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Hugo Kubinyi studied chemistry in Vienna, Austria. He earned his PhD and continued as a PostDoc at the German Cancer Research Centre in Heidelberg. In 1986 he was appointed as associate Professor of Pharmaceutical Chemistry at the University of He...

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Köp böcker av Kubinyi Hugo Kubinyi: Chemogenomics in Drug Discovery: A Medicinal Chemistr...; Chemogenomics in Drug Discovery; Chemoinformatics in Drug Discovery m.fl.

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Hugo Kubinyi 0; Stuart A. Rice 128; Ilya Prigogine 99; Atta-ur-Rahman 96; Alan R. Katritzky 91; Robert C. West 56; Peter Müller 56; Heidi Müller-Dolezal 53; Graham A. Webb 51; Gregory S. Makowski 42; R. Belcher 33; Derek Horton 32; Sam Stuart 30; H. J. Emeléus 30; Hanna Söll 26; A. C. Knipe 26; R. Stuart Tipson 24; Raimund Mannhold 21; Kash L. Mittal 18; A. G. Sharpe 17; Format. Adobe PDF ...

HUGO KUBINYI PDF - PDF Elegant

Hugo Kubinyi, Lectures. By using our website you agree to our use of cookies. Blundell at the Birkbeck College and E. Edited by a former coworker of W thrich, this book presents the theoretical background on NMR of biomolec Density-Functional Theory and Molecular Dynamics: G protein-coupled receptors GPCRs are one of the most important target classes in pharmacology and are the target of many ...

Hugo Kubinyi

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Thermodynamics and Kinetics of Drug Binding Methods and ...

Thermodynamics and Kinetics of Drug Binding Methods and Principles in Medicinal Chemistry, Band 65: Amazon.de: György M. Keserü, David Swinney, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers: Fremdsprachige Bücher

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Hugo Kubinyi-Drug Metabolism_化学_自然科学_专业资料 63人阅读|4次下载. Hugo Kubinyi-Drug Metabolism_化学_自然科学_专业资料。Hugo Kubinyi, www.kubinyi.de Drug Metabolism Hugo Kubinyi Germany E-Mail [email protected] Home

Hit and Lead Profiling von Laszlo Urban, Hugo Kubinyi ...

Finden Sie Top-Angebote für Hit and Lead Profiling von Laszlo Urban, Hugo Kubinyi, Raimund Mannhold, Bernard Faller und Gerd Folkers (2009, Gebundene Ausgabe) bei eBay. Kostenlose Lieferung für viele Artikel!

Hugo Kubinyi - Deutsche Digitale Bibliothek

Hugo Kubinyi. Link auf diese Seite. Hinweis zum Datenschutz Mit Klick auf "Einverstanden" können Sie diese Seite in sozialen Netzwerken weiterempfehlen. Dabei besteht die Möglichkeit, dass Daten von Ihrem Computer zum jeweiligen Anbieter sowie Daten des Anbieters auf Ihren Computer übertragen werden. Diese Zustimmung wird von Ihnen für 24 Stunden erteilt. Sie können die Zustimmung aber ...

Books by Hugo Kubinyi (Author of Wirkstoffdesign)

Hugo Kubinyi has 90 books on Goodreads with 188 ratings. Hugo Kubinyi’s most popular book is Molecular Modeling: Basic Principles And Applications (Metho...

HUGO KUBINYI PDF - icooolps.info

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. The intention is not only to highlight new ideas but also to show the shortcomings, inaccuracies, and abuses of the methods. Hugo Kubinyi, Lectures. The authors, all of them employed at ...

3D QSAR in Drug Design - Recent Advances | Hugo Kubinyi ...

Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series, 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim

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Medicinal Chemistry Approaches to Personalized Medicine ...

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Hugo Kubinyi (Author of Wirkstoffdesign) Pharmacophore Modelling and Molecular Similarity. Applications of Yak and PrGen; M. Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships 3D QSAR since the first publication by Richard Cramer in and the first volume in the series.

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In LitRes digital library you can download the book Data Mining in Drug Discovery by Hugo Kubinyi! Read reviews of the book and write your own at LitRes!

3D QSAR in Drug Design - Volume 1: Theory Methods and ...

Progress in medicinal chemistry and in drug design depends on our ability to understand the interactions of drugs with their biological targets. Classical QSAR studies describe biological activity in terms of physicochemical properties of substituents in certain positions of the drug molecules.

Microwaves in Organic and Medicinal Chemistry (Methods and ...

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Isolierung, Struktur und Partialsynthese biologisch aktiver Naturstoffe aus Crotonöl. Dissertation. von Kubinyi, Hugo und eine große Auswahl ähnlicher Bücher, Kunst und Sammlerstücke erhältlich auf ZVAB.com.

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Hans-Joachim Böhm / Gerhard Klebe / Hugo Kubinyi Wirkstoffdesign Der Weg zum Arzneimittel. Geleitwort VII Vorwort der Autoren und Danksagung IX Einführung 1 Teil I Grundlagen der Arzneimittelforschung 7 1 Arzneimittelforschung gestern, heute, morgen 9 2 Am Anfang stand der glückliche Zufall 3 1 3 Klassische Arzneimittelforschung 45 4 Wie wirkt ein Arzneimittel? 7 3 5 Protein-Ligand ...

QSAR: Hansch Analysis and Related Approaches (eBook, PDF ...

QSAR ist ein Akronym für quantitative Struktur-Wirkung- Beziehung. Dahinter verbergen sich Methoden, die sich nichts Geringeres zum Ziel gesetzt haben, als neue Medikamente zur Behandlung bestimmter Krankheiten gezielt zu entwickeln, nämlich ausgehend von den molekularen Strukturen.

80th Birthday: Hugo Kubinyi :: News :: ChemistryViews

Hugo Kubinyi studied chemistry in Vienna, Austria. He received his Ph.D. from the Max Planck Institute of Biochemistry in Munich, Germany, in 1965. He then served as a postdoctoral researcher at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg. In 1966, he joined Knoll AG, Ludwigshafen, later a subsidiary of BASF AG (today BASF SE). In 1985, he moved to ...

HUGO KUBINYI PDF - linkownik.info

Hugo Kubinyi (Author of Wirkstoffdesign) As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. We use cookies to give you the best possible experience.

QSAR, QSAR: Hansch Analysis and Related Approaches - Hugo ...

Hugo Kubinyi is a leading expert in QSAR. Readers will benefit from the author's 20 years of practical experience, from his careful calculations and recalculations of thousands of QSAR equations. Among the topics covered are: - physiocochemical parameters - quantitative models - statistical methods - Hansch analysis - Free Wilson analysis - 3D-QSAR approaches The book can readily be used as a ...

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Professor Hugo Kubinyi, PhD, DSc. serves as Member of Advisory Board of BioSolveIT GmbH. Professor Kubinyi is a Professor of Pharmaceutical Chemistry of. Köp böcker av Hugo Kubinyi: Pharmacokinetics and Metabolism in Drug Design; Chemogenomics in Drug Discovery; Chemoinformatics in Drug Discovery . Author: Vuzil Dougul: Country: Nepal: Language: English (Spanish) Genre: Automotive: Published ...

Hohe Auszeichnung für Professor Dr. Hugo Kubinyi

Univ.-Prof. Dr. Hugo Kubinyi: Professor Kubinyi studierte in Wien, trat nach dem Studium als medizinischer Chemiker in die KNOLL AG Ludwigshafen ein, entwickelte ein teilsynthetisches Herzglykosid (Meproscillarin, 1978 in die Therapie eingeführt). Von 1987 – 2001 war Kubinyi bei BASF verantwortlich für das Molecular Modelling, die Proteinkristallographie und das Wirkstoffdesign, ab 1998 ...

Hugo Kubinyi Fragment-based Approaches in Drug Discovery


This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

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Antonio de la Hoz Microwaves in Organic Synthesis, 2 Volume Set


The third edition of the bestselling two-volume reference covers everything you need to know about microwave technology for synthesis – from the best equipment to nonthermal effects, from solid-support reactions to catalysis. Completely revised and updated with half of the authors completely new to the project, this comprehensive work is clearly divided into two parts on the fundamentals of microwave irradiation, and application of microwaves and synergies with other enabling techniques. Also new to this edition are chapters on on-line monitoring, flow chemistry, combination with ultrasounds and natural products, including multicomponent reactions. An indispensable source for organic, catalytic, physical, and medicinal chemists.

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Hugo Kubinyi Molecular Biology in Medicinal Chemistry


This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

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Wolfgang Brütting Physics of Organic Semiconductors


Filling the gap in the literature currently available, this book presents an overview of our knowledge of the physics behind organic semiconductor devices. Contributions from 18 international research groups cover various aspects of this field, ranging from the growth of organic layers and crystals, their electronic properties at interfaces, their photophysics and electrical transport properties to the application of these materials in such different devices as organic field-effect transistors, photovoltaic cells and organic light-emitting diodes. From the contents: * Excitation Dynamics in Organic Semiconductors * Organic Field-Effect Transistors * Spectroscopy of Organic Semiconductors * Interfaces between Organic Semiconductors and Metals * Analysis and Modeling of Devices * Exciton Formation and Energy Transfer in Organic Light Emitting Diodes * Deposition and Characterization

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Steven Ricke C. Organic Meat Production and Processing


Organic Meat Production and Processing describes the challenges of production, processing and food safety of organic meat. The editors and international collection of authors explore the trends in organic meats and how the meat industry is impacted. Commencing with chapters on the economics, market and regulatory aspects of organic meats, coverage then extends to management issues for organically raised and processed meat animals. Processing, sensory and human health aspects are covered in detail, as are the incidences of foodborne pathogens in organic beef, swine, poultry and other organic meat species. The book concludes by describing pre-harvest control measures for assuring the safety of organic meats. Organic Meat Production and Processing serves as a unique resource for fully understanding the current and potential issues associated with organic meats.

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Takashi Nakanishi Functional Organic Liquids


The first book to comprehensively cover the burgeoning new class of soft materials known as functional organic liquids Functional organic liquids, a new concept in soft matter materials science, exhibit favorable properties compared to amorphous polymers and ionic liquids. They are composed of a functional core unit and a side chain, which induces fluidity even at room temperature. Due to their fluidity, functional organic liquids can adopt any shape and geometry and fulfill their function in stretchable and bendable devices for applications in photovoltaics, organic electronics, biomedicine, and biochemistry. Presented in five parts, this book starts with an overview of the design methods and properties of functional organic liquids. The next three parts focus on the applications of this exciting new class of soft materials in the fields of energy conversion, nanotechnology, and biomaterials. They study the liquids for energy conversion, those containing inorganic nanoclusters, and solvent-free soft biomaterials. Functional Organic Liquids concludes with a comparison in terms of properties and application potential between functional organic liquids and more conventional soft matter such as ionic liquids and liquid metals. -Examines the current state of science and technology for functional organic liquids -Focuses on potential and already realized applications such as functional organic liquids for energy conversion -Stimulates researchers to move forward on future development and applications Functional Organic Liquids is an excellent book for materials scientists, polymer chemists, organic chemists, physical chemists, surface chemists, and surface physicists.

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Chao-Jun Li Silver Catalysis in Organic Synthesis, 2 Volume Set


Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.

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Hugo Kubinyi Proteomics in Drug Research


From skillful handling of the wide range of technologies to successful applications in drug discovery – this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

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Группа авторов Nitrile Oxides, Nitrones and Nitronates in Organic Synthesis


A comprehensive systematization of current novel data in nitrile oxide chemistry, this book authoritatively covers systematic strategies currently used in the preparation and utilization of nitrile oxides, nitrones, and nitronates in organic synthesis. It covers factors governing their stability and includes in-depth information on stable and unstable nitrile oxides. With contributions from leading experts, this is a definitive reference for practicing professionals in organic or medicinal chemistry and an excellent text for students studying organic synthesis.

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Hugo Kubinyi Pharmacokinetics and Metabolism in Drug Design


In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

14828.14 RUR

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